Fluofarma's contract research services in neuroscience focus on central nervous system (CNS) disorders. We offer to validate drug targets and test neuroactive compounds through customized cell-based assays & quantitative biomarker analysis in brain tissues. Our cell-to-tissue approach delivers solid preclinical proof-of- concepts for CNS drug development.
Neurite outgrowth |
Primary neurons & neuronal cell lines |
PF 3.6 |
γ-secretase activity |
Established HeLa cell clone |
PF 3.13 |
Prolactin release |
Rat primary pituitary cells |
PF 9.9 |
Microtubule dynamics in cellulo |
Primary neurons & neuronal cell lines |
PF 9.2 |
Proteasome 20S subunit quantification |
Multiple cellular models |
PF 9.8 |
Lipid peroxidation |
Multiple cellular models |
PF 3.18 |
Nrf2 activation |
Multiple cellular models |
PF 3.19 |
Tau Phosphorylation |
Rat primary cortical neurons |
PF 9.3 |
Amyloid Beta1-42 induced neurotoxicity |
Rat primary cortical neurons |
PF 9.10 |
Bacterial particles phagocytosis |
Rat primary cortical neurons |
PF 9.11 |
NF kB activation |
Multiple cellular models |
PF 3.23 |
Glucocorticoid receptor subcellular translocation |
AtT20/Primary pituitary cells |
PF 3.26 |
ERK activation (pERK1/2) |
Multiple cellular models |
PF 3.27 |
cAMP quantification |
Multiple cellular models |
PF 3.34 |
Calcium signaling (ionotropic and metabotropic receptor pharmacology) |
Ionotropic and metaotropic receptor pharmacology |
PF 3.33 |
Poly-Ubiquitin detection |
Multiple cellular models |
PF 3.28 |
Heme Oxygenase 1 expression |
Multiple cellular models |
PF 3.25 |
FKBP52 |
Multiple cellular models |
PF 9.6 |
CREB phosphorylation |
Multiple cellular models |
PF 3.35 |
NeuroToxicity: gliosis |
Primary cultures |
PF 9.7 |
Neuromuscular junction quantification |
Co-culture of mouse myotubes and primary spinal cord neurons |
PF 9.4 |
Caspase 3/7 activity |
Multiple established cell clones |
PF 3.1 |
Caspase 3/7 activation |
Multiple cellular models |
PF 3.2 |
Mitochondrial Membrane Potential |
Multiple cellular models |
PF 3.3 |
Cytolysis |
Multiple cellular models |
PF 3.4 |
Intracellular reactive oxygen species |
Multiple cellular models |
PF 3.11 |
Calpain activity |
Multiple established cell clones |
PF 3.12 |
NQO1 expression |
Multiple cellular models |
PF 3.24 |
Monoamine oxidase B activity |
HepG2 cell line |
PF 9.1 |
Myelin Basic Protein (MBP) quantification |
Multiple cellular models |
PF 9.5 |