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NEUROBIOLOGY

Fluofarma's contract research services in neuroscience focus on central nervous system (CNS) disorders. We offer to validate drug targets and test neuroactive compounds through customized cell-based assays & quantitative biomarker analysis in brain tissues. Our cell-to-tissue approach delivers solid preclinical proof-of- concepts for CNS drug development.

PRIMARY NERVE
CELL CULTURES

NEUROSCIENCE CELL-BASED ASSAYS

ALZHEIMER'S DISEASE & TAUOPATHY

PARKINSON'S
DISEASE

IN VIVO NEUROSCIENCE SERVICES

BRAIN TISSUE
ANALYSIS

NEURO
ONCOLOGY

NEUROBIOLOGY READOUTS

Neurite outgrowth	Primary neurons & neuronal cell lines	PF 3.6
γ-secretase activity	Established HeLa cell clone	PF 3.13
Prolactin release	Rat primary pituitary cells	PF 9.9
Microtubule dynamics in cellulo	Primary neurons & neuronal cell lines	PF 9.2
Proteasome 20S subunit quantification	Multiple cellular models	PF 9.8
Lipid peroxidation	Multiple cellular models	PF 3.18
Nrf2 activation	Multiple cellular models	PF 3.19
Tau Phosphorylation	Rat primary cortical neurons	PF 9.3
Amyloid Beta1-42 induced neurotoxicity	Rat primary cortical neurons	PF 9.10
Bacterial particles phagocytosis	Rat primary cortical neurons	PF 9.11
NF kB activation	Multiple cellular models	PF 3.23
Glucocorticoid receptor subcellular translocation	AtT20/Primary pituitary cells	PF 3.26
ERK activation (pERK1/2)	Multiple cellular models	PF 3.27
cAMP quantification	Multiple cellular models	PF 3.34
Calcium signaling (ionotropic and metabotropic receptor pharmacology)	Ionotropic and metaotropic receptor pharmacology	PF 3.33
Poly-Ubiquitin detection	Multiple cellular models	PF 3.28
Heme Oxygenase 1 expression	Multiple cellular models	PF 3.25
FKBP52	Multiple cellular models	PF 9.6
CREB phosphorylation	Multiple cellular models	PF 3.35
NeuroToxicity: gliosis	Primary cultures	PF 9.7
Neuromuscular junction quantification	Co-culture of mouse myotubes and primary spinal cord neurons	PF 9.4
Caspase 3/7 activity	Multiple established cell clones	PF 3.1
Caspase 3/7 activation	Multiple cellular models	PF 3.2
Mitochondrial Membrane Potential	Multiple cellular models	PF 3.3
Cytolysis	Multiple cellular models	PF 3.4
Intracellular reactive oxygen species	Multiple cellular models	PF 3.11
Calpain activity	Multiple established cell clones	PF 3.12
NQO1 expression	Multiple cellular models	PF 3.24
Monoamine oxidase B activity	HepG2 cell line	PF 9.1
Myelin Basic Protein (MBP) quantification	Multiple cellular models	PF 9.5

NEUROBIOLOGY

NEUROBIOLOGY READOUTS

Fluofarma

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