METABOLIC DISEASES

>  in vitro models based on primary cell cultures or cell lines: adipocytes, hepatocytes, pancreatic cells, etc...

>  Metabolism assays: lipolysis assays, lipids and phospholipids accumulation, lipid peroxidation, LDL uptake, NADH/FAD content, ATP content, intracellular ROS, P-glycoprotein (P-gp) activity, intracellular Glutathione (GSH) content, hepatobiliary function, ...

>  Neuroendocrinology-related assays: prolactin release and dopamine metabolism, glucocorticoid receptor translocation, etc...

>>> Check our general assay portfolio

Through PORSOLT capabilities, we offer to perform in vivo studies in predictive models of metabolic syndrome:

> Genetic and diet-induced in vivo models of obesity (Ob/Ob genetic model and high fat diet-induced obesity model) and diabetes (Db/Db genetic model and high fat diet-induced diabetes model)

> LC-MS/MS analysis: Detection of metabolic factors, cytokines, etc., on tissue lysate or blood & derivatives (PBMC & blood samples, monocytes, macrophages,...)

> High content histology: Automated tissue imaging and multiplexed analysis of key markers with single-cell resolution (biomarker expression levels & subcellular localization).