Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.
CELLULAR MODELS
ANALYSIS IN BLOOD SAMPLES
INFLAMMATION ASSAYS
IMMUNOLOGY , CELL SUBSETS IMMUNOPHENOTYPING & IMMUNE CELL RESPONSE
Immunophenotyping (Immune cell subpopulation determination) |
Multiple cellular models fresh biological samples |
PF 5.6 |
Multiplexed analysis of protein release Cytometric Based Array |
Mouse - Rat - Human |
PF 5.8 |
IL-1β release |
Multiple cellular models | PF 5.3 |
TNFα release |
Multiple cellular models | PF 5.4 |
IL-6 release |
Multiple cellular models | PF 5.5 |
CELL PHYSIOLOGY AND METABOLISM
NEW ! Immune cell activation and proliferation |
Primary mouse splenocytes | PF 5.8 |
Cell Migration |
Multiple cellular models | PF 3.14 |
Autophagy (LC3B) |
Multiple cellular models | PF 3.17 |
Cell proliferation |
Multiple cellular models | PF 3.9 |
Lipid peroxidation |
Multiple cellular models | PF 3.18 |
Cytolysis |
Multiple cellular models | PF 3.4 |
Mitochondrial membrane potential |
Multiple cellular models | PF 3.3 |
Caspase 3/7 activation |
Multiple cellular models | PF 3.2 |
Caspase 1 activation |
Multiple cellular models | PF 5.2 |
CELL SIGNALING
NEW ! Endothelial cell activation |
HUVECs | PF 5.9 |
NF κB activation/p65 phosphorylation |
Multiple cellular models | PF 3.23 |
ERK activation (pERK1/2) |
Multiple cellular models | PF 3.27 |
Calcium signaling |
Multiple cellular models | PF 3.33 |
STAT1 translocation |
Multiple cellular models | PF 3.36 |
STAT2 translocation |
Multiple cellular models | PF 3.35 |
STAT3 translocation |
Multiple cellular models | PF 3.30 |
STAT6 phosphorylation |
Multiple cellular models | PF 3.34 |
c-Jun phosphorylation |
Multiple cellular models | PF 3.45 |
Capacitative calcium entry |
HEK293 cell line | PF 5.7 |
Poly-Ubiquitin detection |
Multiple cellular models | PF 3.38 |
Histone H2AX phosphorylation |
Multiple cellular models | PF 5.1 |