INFLAMMATION

INFLAMMATION

Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.

CELLULAR MODELS

CELLULAR MODELS

ANALYSIS IN BLOOD SAMPLES

ANALYSIS IN BLOOD SAMPLES

INFLAMMATION ASSAYS

INFLAMMATION ASSAYS

IMMUNOLOGY  , CELL SUBSETS IMMUNOPHENOTYPING & IMMUNE CELL RESPONSE 

Immunophenotyping
(Immune cell subpopulation determination)		 Multiple cellular models
fresh biological samples		 PF 5.6
NEW ! Multiplexed analysis of protein release Mouse PF 5.8

IL-1β release

 Multiple cellular models PF 5.3

TNFα release

 Multiple cellular models PF 5.4

IL-6 release

 Multiple cellular models PF 5.5

CELL PHYSIOLOGY AND METABOLISM

Cell Migration
(Transwell chamber-based)

 Multiple cellular models PF 3.14

Autophagy (LC3B)

 Multiple cellular models PF 3.17

Cell proliferation

 Multiple cellular models PF 3.9

Lipid peroxidation

 Multiple cellular models PF 3.18

Cytolysis

 Multiple cellular models PF 3.4

Mitochondrial membrane potential

 Multiple cellular models PF 3.3

Caspase 3/7 activation

 Multiple cellular models PF 3.2

Caspase 1 activation

 Multiple cellular models PF 5.2

CELL SIGNALING

NF κB activation/p65 phosphorylation

 Multiple cellular models PF 3.23

ERK activation (pERK1/2)

 Multiple cellular models PF 3.27

Calcium signaling

 Multiple cellular models PF 3.33

STAT1 translocation

 Multiple cellular models PF 3.36

STAT2 translocation

 Multiple cellular models PF 3.35

STAT3 translocation

 Multiple cellular models PF 3.30

STAT6 phosphorylation

 Multiple cellular models PF 3.34

c-Jun phosphorylation

 Multiple cellular models PF 3.45

NEW Capacitative calcium entry

 HEK293 cell line PF 5.7

Poly-Ubiquitin detection

 Multiple cellular models PF 3.38

Histone H2AX phosphorylation

 Multiple cellular models PF 5.1

ADDITIONAL CAPABILITIES