DERMATOLOGY

DERMATOLOGY

Dermatological diseases represent a major health problem due to the substantial patient population that is affected. Psoriasis, Allergic Contact Dermatitis (ACD) and Atopical Dermatitis (Allergic or Irritant Contact Dermatitis) are the major skin diseases of immunological origin.

DERMATOLOGY READOUTS

Cytolysis

Multiple cellular models PF 3.4

Cell cycle

Multiple cellular models PF 3.8

Cell proliferation

Multiple cellular models PF 3.9

Cell migration wound healing

Multiple cellular models PF 3.14

Autophagy (LC3B)

Multiple cellular models PF 3.17

NF κB activation

Multiple cellular models PF 3.23

cAMP quantification

Multiple cellular models PF 3.34

Mitochondrial Membrane Potential

Multiple cellular models PF 3.3

Glycerol release/lipolysis

Adipocytes PF 7.1

Lipid, intracellular accumulation: neutral lipids

Multiple cellular models PF 3.29

Lipid, intracellular accumulation: phospholipids

Multiple cellular models PF 3.30

TNFalpha -induced cytotoxicity

L929 cell line PF 4.1
H2O2-induced oxidative damage Keratinocytes PF 4.2

APPLICATION IN DERMATOLOGY DEVELOPMENT

ADDITIONAL CAPABILITIES - in vivo models