CELL INFLAMMATION

Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.

HIGH-CONTENT ANALYSIS OF INFLAMMATION MARKERS

 

Fluofarma assesses the effects of compounds modulating inflammatory pathways at the single-cell level, using automated high-content imaging.

 

For instance, the following signaling pathways can be monitored in 2D & 3D cell cultures and tissues samples: 

> iNOS activation,

> NF-κB translocation,

> Heme O1, STAT3 ...

CYTOKINES & CHEMOKINES ASSAYS

In addition, Fluofarma can detect a large panel of cytokines & chemokines in cellular models or blood samples using ELISA, flow cytometry.